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Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer’s disease (AD)...

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Detalles Bibliográficos
Autores principales:	Shanbhag, Niraj M., Evans, Mark D., Mao, Wenjie, Nana, Alissa L., Seeley, William W., Adame, Anthony, Rissman, Robert A., Masliah, Eliezer, Mucke, Lennart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524256/ https://www.ncbi.nlm.nih.gov/pubmed/31101070 http://dx.doi.org/10.1186/s40478-019-0723-5

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