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Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

BACKGROUND: Preclinical studies suggest synergistic effectiveness of ascorbic acid (AA, vitamin C) and cytotoxic agents in gastrointestinal malignancies. This phase 1 study aimed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of AA combined with mFOLFOX6 or FOLFIRI...

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Detalles Bibliográficos
Autores principales:	Wang, Feng, He, Ming-Ming, Wang, Zi-Xian, Li, Su, Jin, Ying, Ren, Chao, Shi, Si-Mei, Bi, Bing-Tian, Chen, Shuang-Zhen, Lv, Zhi-Da, Hu, Jia-Jia, Wang, Zhi-Qiang, Wang, Feng-Hua, Wang, De-Shen, Li, Yu-Hong, Xu, Rui-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524297/ https://www.ncbi.nlm.nih.gov/pubmed/31096937 http://dx.doi.org/10.1186/s12885-019-5696-z

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