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Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment
Discogenic back pain is multifactorial; hence, physicians often struggle to identify the underlying source of the pain. As a result, discogenic back pain is often hard to treat—even more so when clinical treatment strategies are of questionable efficacy. Based on a broad literature review, our aim w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524679/ https://www.ncbi.nlm.nih.gov/pubmed/31131347 http://dx.doi.org/10.1002/jbm4.10180 |
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author | Fujii, Kengo Yamazaki, Masashi Kang, James D Risbud, Makarand V Cho, Samuel K Qureshi, Sheeraz A Hecht, Andrew C Iatridis, James C |
author_facet | Fujii, Kengo Yamazaki, Masashi Kang, James D Risbud, Makarand V Cho, Samuel K Qureshi, Sheeraz A Hecht, Andrew C Iatridis, James C |
author_sort | Fujii, Kengo |
collection | PubMed |
description | Discogenic back pain is multifactorial; hence, physicians often struggle to identify the underlying source of the pain. As a result, discogenic back pain is often hard to treat—even more so when clinical treatment strategies are of questionable efficacy. Based on a broad literature review, our aim was to define discogenic back pain into a series of more specific and interacting pathologies, and to highlight the need to develop novel approaches and treatment strategies for this challenging and unmet clinical need. Discogenic pain involves degenerative changes of the intervertebral disc, including structural defects that result in biomechanical instability and inflammation. These degenerative changes in intervertebral discs closely intersect with the peripheral and central nervous systems to cause nerve sensitization and ingrowth; eventually central sensitization results in a chronic pain condition. Existing imaging modalities are nonspecific to pain symptoms, whereas discography methods that are more specific have known comorbidities based on intervertebral disc puncture and injection. As a result, alternative noninvasive and specific diagnostic methods are needed to better diagnose and identify specific conditions and sources of pain that can be more directly treated. Currently, there are many treatments/interventions for discogenic back pain. Nevertheless, many surgical approaches for discogenic pain have limited efficacy, thus accentuating the need for the development of novel treatments. Regenerative therapies, such as biologics, cell‐based therapy, intervertebral disc repair, and gene‐based therapy, offer the most promise and have many advantages over current therapies. © 2019 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research |
format | Online Article Text |
id | pubmed-6524679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65246792019-05-24 Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment Fujii, Kengo Yamazaki, Masashi Kang, James D Risbud, Makarand V Cho, Samuel K Qureshi, Sheeraz A Hecht, Andrew C Iatridis, James C JBMR Plus Perspective Discogenic back pain is multifactorial; hence, physicians often struggle to identify the underlying source of the pain. As a result, discogenic back pain is often hard to treat—even more so when clinical treatment strategies are of questionable efficacy. Based on a broad literature review, our aim was to define discogenic back pain into a series of more specific and interacting pathologies, and to highlight the need to develop novel approaches and treatment strategies for this challenging and unmet clinical need. Discogenic pain involves degenerative changes of the intervertebral disc, including structural defects that result in biomechanical instability and inflammation. These degenerative changes in intervertebral discs closely intersect with the peripheral and central nervous systems to cause nerve sensitization and ingrowth; eventually central sensitization results in a chronic pain condition. Existing imaging modalities are nonspecific to pain symptoms, whereas discography methods that are more specific have known comorbidities based on intervertebral disc puncture and injection. As a result, alternative noninvasive and specific diagnostic methods are needed to better diagnose and identify specific conditions and sources of pain that can be more directly treated. Currently, there are many treatments/interventions for discogenic back pain. Nevertheless, many surgical approaches for discogenic pain have limited efficacy, thus accentuating the need for the development of novel treatments. Regenerative therapies, such as biologics, cell‐based therapy, intervertebral disc repair, and gene‐based therapy, offer the most promise and have many advantages over current therapies. © 2019 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research John Wiley and Sons Inc. 2019-03-04 /pmc/articles/PMC6524679/ /pubmed/31131347 http://dx.doi.org/10.1002/jbm4.10180 Text en © 2019 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Fujii, Kengo Yamazaki, Masashi Kang, James D Risbud, Makarand V Cho, Samuel K Qureshi, Sheeraz A Hecht, Andrew C Iatridis, James C Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title | Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title_full | Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title_fullStr | Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title_full_unstemmed | Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title_short | Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment |
title_sort | discogenic back pain: literature review of definition, diagnosis, and treatment |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524679/ https://www.ncbi.nlm.nih.gov/pubmed/31131347 http://dx.doi.org/10.1002/jbm4.10180 |
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