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Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-Mediated Rag2 and IL2rg Mutation

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas)9 is a novel and convenient gene editing system that can be used to construct genetically modified animals. Recombination activating gene 2 (Rag2) is a core component that is involved in the initiation of V(D)J...

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Detalles Bibliográficos
Autores principales:	Zhao, Yong, Liu, Peijuan, Xin, Zhiqian, Shi, Changhong, Bai, Yinlan, Sun, Xiuxuan, Zhao, Ya, Wang, Xiaoya, Liu, Li, Zhao, Xuan, Chen, Zhinan, Zhang, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524690/ https://www.ncbi.nlm.nih.gov/pubmed/31134127 http://dx.doi.org/10.3389/fgene.2019.00401

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