Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of amino...

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Detalles Bibliográficos
Autores principales: Sobhi Siha, Mona, Abdel-Hamid Shaker, Dalia, Teleb, Hebatalla Saad, Ahmed Rashed, Laila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz: NIOC Health Organization 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524739/
https://www.ncbi.nlm.nih.gov/pubmed/31041926
http://dx.doi.org/10.15171/ijoem.2019.1629
Descripción
Sumario:Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

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