Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of amino...

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Autores principales: Sobhi Siha, Mona, Abdel-Hamid Shaker, Dalia, Teleb, Hebatalla Saad, Ahmed Rashed, Laila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz: NIOC Health Organization 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524739/
https://www.ncbi.nlm.nih.gov/pubmed/31041926
http://dx.doi.org/10.15171/ijoem.2019.1629
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author Sobhi Siha, Mona
Abdel-Hamid Shaker, Dalia
Teleb, Hebatalla Saad
Ahmed Rashed, Laila
author_facet Sobhi Siha, Mona
Abdel-Hamid Shaker, Dalia
Teleb, Hebatalla Saad
Ahmed Rashed, Laila
author_sort Sobhi Siha, Mona
collection PubMed
description Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.
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spelling pubmed-65247392019-05-28 Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers Sobhi Siha, Mona Abdel-Hamid Shaker, Dalia Teleb, Hebatalla Saad Ahmed Rashed, Laila Int J Occup Environ Med Brief Report Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity. Shiraz: NIOC Health Organization 2019-04-01 /pmc/articles/PMC6524739/ /pubmed/31041926 http://dx.doi.org/10.15171/ijoem.2019.1629 Text en This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) .
spellingShingle Brief Report
Sobhi Siha, Mona
Abdel-Hamid Shaker, Dalia
Teleb, Hebatalla Saad
Ahmed Rashed, Laila
Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title_full Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title_fullStr Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title_full_unstemmed Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title_short Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers
title_sort effects of delta-aminolevulinic acid dehydratase gene polymorphism on hematological parameters and kidney function of lead-exposed workers
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524739/
https://www.ncbi.nlm.nih.gov/pubmed/31041926
http://dx.doi.org/10.15171/ijoem.2019.1629
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