HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression

Understanding oxidative stress and HTRA1 locus in abnormal angiogenesis resulting in wet AMD pathology is an important step in developing a novel therapeutic approach. Using subretinal injection of oxLDL into C57BL/6 mice, we observed a lesion resembling the features of choroidal neovascularization...

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Detalles Bibliográficos
Autores principales: Lu, Zhigang, Lin, Victor, May, Adam, Che, Briana, Xiao, Xu, Shaw, Daniel H., Su, Fei, Wang, Zhihao, Du, Hongjun, Shaw, Peter X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524793/
https://www.ncbi.nlm.nih.gov/pubmed/31100080
http://dx.doi.org/10.1371/journal.pone.0216808

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