TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular and cellular defects, however, remain unclea...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Peng, Deng, Jianwen, Dong, Jie, Liu, Jianghong, Bigio, Eileen H., Mesulam, Marsel, Wang, Tao, Sun, Lei, Wang, Li, Lee, Alan Yueh-Luen, McGee, Warren A., Chen, Xiaoping, Fushimi, Kazuo, Zhu, Li, Wu, Jane Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524796/
https://www.ncbi.nlm.nih.gov/pubmed/31100073
http://dx.doi.org/10.1371/journal.pgen.1007947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524796/
https://www.ncbi.nlm.nih.gov/pubmed/31100073
http://dx.doi.org/10.1371/journal.pgen.1007947

Ejemplares similares