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TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular and cellular defects, however, remain unclea...

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Detalles Bibliográficos
Autores principales:	Wang, Peng, Deng, Jianwen, Dong, Jie, Liu, Jianghong, Bigio, Eileen H., Mesulam, Marsel, Wang, Tao, Sun, Lei, Wang, Li, Lee, Alan Yueh-Luen, McGee, Warren A., Chen, Xiaoping, Fushimi, Kazuo, Zhu, Li, Wu, Jane Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524796/ https://www.ncbi.nlm.nih.gov/pubmed/31100073 http://dx.doi.org/10.1371/journal.pgen.1007947

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