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Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in Kras(G12D) mice

We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells. Exposure of sparse cultures of PANC-1 and MiaPaCa-2 cells to cerivastatin or simvastatin induced a striking r...

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Detalles Bibliográficos
Autores principales:	Hao, Fang, Xu, Qinhong, Wang, Jing, Yu, Shuo, Chang, Hui-Hua, Sinnett-Smith, James, Eibl, Guido, Rozengurt, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524808/ https://www.ncbi.nlm.nih.gov/pubmed/31100067 http://dx.doi.org/10.1371/journal.pone.0216603

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