Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia

Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin...

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Autores principales: Martini, Francesca, Cecconi, Nadia, Paolicchi, Aldo, Galimberti, Sara, Cervetti, Giulia, Buda, Gabriele, Petrini, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524915/
https://www.ncbi.nlm.nih.gov/pubmed/31249984
http://dx.doi.org/10.1055/s-0039-1683969
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author Martini, Francesca
Cecconi, Nadia
Paolicchi, Aldo
Galimberti, Sara
Cervetti, Giulia
Buda, Gabriele
Petrini, Mario
author_facet Martini, Francesca
Cecconi, Nadia
Paolicchi, Aldo
Galimberti, Sara
Cervetti, Giulia
Buda, Gabriele
Petrini, Mario
author_sort Martini, Francesca
collection PubMed
description Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed.
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spelling pubmed-65249152019-06-27 Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia Martini, Francesca Cecconi, Nadia Paolicchi, Aldo Galimberti, Sara Cervetti, Giulia Buda, Gabriele Petrini, Mario TH Open Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed. Georg Thieme Verlag KG 2019-03-19 /pmc/articles/PMC6524915/ /pubmed/31249984 http://dx.doi.org/10.1055/s-0039-1683969 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Martini, Francesca
Cecconi, Nadia
Paolicchi, Aldo
Galimberti, Sara
Cervetti, Giulia
Buda, Gabriele
Petrini, Mario
Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title_full Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title_fullStr Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title_full_unstemmed Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title_short Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia
title_sort interference of monoclonal gammopathy with fibrinogen assay producing spurious dysfibrinogenemia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524915/
https://www.ncbi.nlm.nih.gov/pubmed/31249984
http://dx.doi.org/10.1055/s-0039-1683969
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