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A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation
Besides AP-2 and clathrin triskelia, clathrin coat inception depends on a group of early-arriving proteins including Fcho1/2 and Eps15/R. Using genome-edited cells, we described the role of the unstructured Fcho linker in stable AP-2 membrane deposition. Here, expanding this strategy in combination...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524969/ https://www.ncbi.nlm.nih.gov/pubmed/31038455 http://dx.doi.org/10.7554/eLife.41768 |