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Vitamin D (1,25(OH)(2)D3) induces α-1-antitrypsin synthesis by CD4(+) T cells, which is required for 1,25(OH)(2)D3-driven IL-10

Studies to identify novel immune-regulatory functions of active vitamin D (1,25(OH)(2)D3) in human CD4(+) T cells revealed that 1,25(OH)(2)D3 potently induced expression of the gene SERPINA1, encoding the anti-protease α-1-antitrypsin. We confirmed α-1-antitrypsin protein expression by 1,25(OH)(2)D3...

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Detalles Bibliográficos
Autores principales:	Dimeloe, Sarah, Rice, Louise V., Chen, Hebe, Cheadle, Charlotte, Raynes, John, Pfeffer, Paul, Lavender, Paul, Richards, David F., Nyon, Mun Peak, McDonnell, James M., Kemper, Claudia, Gooptu, Bibek, Hawrylowicz, Catherine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525112/ https://www.ncbi.nlm.nih.gov/pubmed/30690074 http://dx.doi.org/10.1016/j.jsbmb.2019.01.014

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