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15-deoxy-Δ(12,14)-Prostaglandin J(2) inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
Human soluble epoxide hydrolase (hsEH) is an enzyme responsible for the inactivation of bioactive epoxy fatty acids, and its inhibition is emerging as a promising therapeutical strategy to target hypertension, cardiovascular disease, pain and insulin sensitivity. Here, we uncover the molecular bases...
Autores principales: | Abis, Giancarlo, Charles, Rebecca L., Kopec, Jolanta, Yue, Wyatt W., Atkinson, R. Andrew, Bui, Tam T. T., Lynham, Steven, Popova, Simona, Sun, Yin-Biao, Fraternali, Franca, Eaton, Philip, Conte, Maria R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525171/ https://www.ncbi.nlm.nih.gov/pubmed/31123712 http://dx.doi.org/10.1038/s42003-019-0426-2 |
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