CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes

Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3) via activities of very long chain fatty acyl elongases (Elovls) and fatty acyl desaturases (Fads), albeit to a limited degree. Un...

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Detalles Bibliográficos
Autores principales: Datsomor, Alex K., Zic, Nikola, Li, Keshuai, Olsen, Rolf E., Jin, Yang, Vik, Jon Olav, Edvardsen, Rolf B., Grammes, Fabian, Wargelius, Anna, Winge, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525179/
https://www.ncbi.nlm.nih.gov/pubmed/31101849
http://dx.doi.org/10.1038/s41598-019-43862-8

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