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Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks
In mammalian cells, double-stranded DNA breaks (DSBs) are preferentially repaired through end-joining processes that generally lead to mixtures of insertions and deletions (indels) or other rearrangements at the cleavage site. In the presence of homologous DNA, homology-directed repair (HDR) can gen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525190/ https://www.ncbi.nlm.nih.gov/pubmed/31101808 http://dx.doi.org/10.1038/s41467-019-09983-4 |