Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP. Deficie...

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Detalles Bibliográficos
Autores principales: Fox, Nicholas G., Yu, Xiaodi, Feng, Xidong, Bailey, Henry J., Martelli, Alain, Nabhan, Joseph F., Strain-Damerell, Claire, Bulawa, Christine, Yue, Wyatt W., Han, Seungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525205/
https://www.ncbi.nlm.nih.gov/pubmed/31101807
http://dx.doi.org/10.1038/s41467-019-09989-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525205/
https://www.ncbi.nlm.nih.gov/pubmed/31101807
http://dx.doi.org/10.1038/s41467-019-09989-y

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