Cargando…

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP. Deficie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fox, Nicholas G., Yu, Xiaodi, Feng, Xidong, Bailey, Henry J., Martelli, Alain, Nabhan, Joseph F., Strain-Damerell, Claire, Bulawa, Christine, Yue, Wyatt W., Han, Seungil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525205/ https://www.ncbi.nlm.nih.gov/pubmed/31101807 http://dx.doi.org/10.1038/s41467-019-09989-y

Ejemplares similares

In vivo overexpression of frataxin causes toxicity mediated by iron-sulfur cluster deficiency
por: Huichalaf, Claudia, et al.
Publicado: (2022)

Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly
por: Cai, Kai, et al.
Publicado: (2018)

Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex
por: Schmucker, Stéphane, et al.
Publicado: (2011)

Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin
por: Nabhan, Joseph F., et al.
Publicado: (2015)

A Highly Conserved Iron-Sulfur Cluster Assembly Machinery between Humans and Amoeba Dictyostelium discoideum: The Characterization of Frataxin
por: Olmos, Justo, et al.
Publicado: (2020)

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry
por: Bridwell-Rabb, Jennifer, et al.
Publicado: (2014)

Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly
por: Prischi, Filippo, et al.
Publicado: (2010)

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity
por: Fox, Nicholas G., et al.
Publicado: (2018)

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin
por: Gervason, Sylvain, et al.
Publicado: (2019)

[2Fe-2S]-Ferredoxin Binds Directly to Cysteine Desulfurase and Supplies an Electron for Iron–Sulfur Cluster Assembly but Is Displaced by the Scaffold Protein or Bacterial Frataxin
por: Kim, Jin Hae, et al.
Publicado: (2013)

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia
por: Nabhan, Joseph F., et al.
Publicado: (2016)

Assembly and Transfer of Iron–Sulfur Clusters in the Plastid
por: Lu, Yan
Publicado: (2018)

Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation
por: Martelli, Alain, et al.
Publicado: (2014)

The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification
por: Swift, Russell P, et al.
Publicado: (2023)

Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe–S cluster assembly centers
por: Galeano, B. K., et al.
Publicado: (2017)

Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron–sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin
por: Sutak, Robert, et al.
Publicado: (2012)

Bridging a gap in iron-sulfur cluster assembly
por: McCarthy, Erin L., et al.
Publicado: (2015)

Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease
por: Ye, Hong, et al.
Publicado: (2010)

Iron-regulated assembly of the cytosolic iron–sulfur cluster biogenesis machinery
por: Fan, Xiaorui, et al.
Publicado: (2022)

Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL-l-METHIONINE ACTIVATION
por: McCorvie, Thomas J., et al.
Publicado: (2014)

Molecular Details of the Frataxin–Scaffold Interaction during Mitochondrial Fe–S Cluster Assembly
por: Campbell, Courtney J., et al.
Publicado: (2021)

Iron-Sulfur Cluster Complex Assembly in the Mitochondria of Arabidopsis thaliana
por: Armas, Alejandro M., et al.
Publicado: (2020)

Bacterial Approaches for Assembling Iron-Sulfur Proteins
por: Esquilin-Lebron, Karla, et al.
Publicado: (2021)

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
por: Li, Kuanyu, et al.
Publicado: (2008)

The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions
por: Couturier, Jérémy, et al.
Publicado: (2013)

Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine
por: Jordan, Sean F., et al.
Publicado: (2021)

Solution Structure of the Iron−Sulfur Cluster Cochaperone HscB and Its Binding Surface for the Iron−Sulfur Assembly Scaffold Protein IscU
por: Füzéry, Anna K., et al.
Publicado: (2008)

Molecular Insights into Frataxin-Mediated Iron Supply for Heme Biosynthesis in Bacillus subtilis
por: Mielcarek, Andreas, et al.
Publicado: (2015)

SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY
por: Fekry, Mostafa, et al.
Publicado: (2017)

Protoporphyrin IX Binds to Iron(II)-Loaded and to Zinc-Loaded Human Frataxin
por: Bernardo-Seisdedos, Ganeko, et al.
Publicado: (2023)

Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich’s ataxia
por: Hackett, Peter T., et al.
Publicado: (2022)

IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy
por: Ishiyama, Akihiko, et al.
Publicado: (2017)

Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells
por: Wong, Andy On-Tik, et al.
Publicado: (2019)

Plant Frataxin in Metal Metabolism
por: Gomez-Casati, Diego F., et al.
Publicado: (2018)

Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron–sulfur cluster assembly
por: Bennett, Sophie P., et al.
Publicado: (2022)

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
por: Chen, Kuchuan, et al.
Publicado: (2016)

Iron–Sulfur Cluster Biogenesis and Iron Homeostasis in Cyanobacteria
por: Gao, Fudan
Publicado: (2020)

Iron-induced oligomerization of human FXN(81-210) and bacterial CyaY frataxin and the effect of iron chelators
por: Ahlgren, Eva-Christina, et al.
Publicado: (2017)

Erythropoiesis and Iron Sulfur Cluster Biogenesis
por: Ye, Hong, et al.
Publicado: (2010)

Respiratory chain supercomplexes associate with the cysteine desulfurase complex of the iron–sulfur cluster assembly machinery
por: Böttinger, Lena, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i94cb7rh0ppvodvjqjmngljkor