The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining

DNA double-strand breaks (DSBs) are one of the most lethal forms of DNA damage that is not efficiently repaired in prokaryotes. Certain microorganisms can handle chromosomal DSBs using the error-prone non-homologous end joining (NHEJ) system and ultimately cause genome mutagenesis. Here, we demonstr...

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Detalles Bibliográficos
Autores principales: Su, Tianyuan, Liu, Fapeng, Chang, Yizhao, Guo, Qi, Wang, Junshu, Wang, Qian, Qi, Qingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525309/
https://www.ncbi.nlm.nih.gov/pubmed/31193309
http://dx.doi.org/10.1016/j.synbio.2019.04.001

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