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Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

BACKGROUND: The VRK1 chromatin kinase regulates the organization of locally altered chromatin induced by DNA damage. The combination of ionizing radiation with inhibitors of DNA damage responses increases the accumulation of DNA damage in cancer cells, which facilitates their antitumor effect, a pro...

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Detalles Bibliográficos
Autores principales:	Campillo-Marcos, Ignacio, Lazo, Pedro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525392/ https://www.ncbi.nlm.nih.gov/pubmed/31101118 http://dx.doi.org/10.1186/s13046-019-1204-1

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