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Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

BACKGROUND: Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalling is initiated by binding of IL-6 to the IL-6 receptor α and subsequent bindin...

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Detalles Bibliográficos
Autores principales:	Reeh, Heike, Rudolph, Nadine, Billing, Ulrike, Christen, Henrike, Streif, Stefan, Bullinger, Eric, Schliemann-Bullinger, Monica, Findeisen, Rolf, Schaper, Fred, Huber, Heinrich J., Dittrich, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525395/ https://www.ncbi.nlm.nih.gov/pubmed/31101051 http://dx.doi.org/10.1186/s12964-019-0356-0

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