The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

BACKGROUND: Glioblastoma multiforme (GBM), due to its location, aggressiveness, heterogeneity and infiltrative growth, is characterized by an exceptionally dismal clinical outcome. The small molecule SI113, recently identified as a SGK1 inhibitor, has proven to be effective in restraining GBM growth...

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Detalles Bibliográficos
Autores principales: Matteoni, Silvia, Abbruzzese, Claudia, Matarrese, Paola, De Luca, Gabriele, Mileo, Anna M., Miccadei, Stefania, Schenone, Silvia, Musumeci, Francesca, Haas, Tobias L., Sette, Giovanni, Carapella, Carmine M., Amato, Rosario, Perrotti, Nicola, Signore, Michele, Paggi, Marco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525441/
https://www.ncbi.nlm.nih.gov/pubmed/31101126
http://dx.doi.org/10.1186/s13046-019-1212-1

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