Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Next generation sequencing (NGS)-based tumor profiling identified an overwhelming number of uncharacterized somatic mutations, also known as variants of unknown significance (VUS). The therapeutic significance of EGFR mutations outside mutational hotspots, consisting of >50 types, in nonsmall cel...

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Detalles Bibliográficos
Autores principales: Ikemura, Shinnosuke, Yasuda, Hiroyuki, Matsumoto, Shingo, Kamada, Mayumi, Hamamoto, Junko, Masuzawa, Keita, Kobayashi, Keigo, Manabe, Tadashi, Arai, Daisuke, Nakachi, Ichiro, Kawada, Ichiro, Ishioka, Kota, Nakamura, Morio, Namkoong, Ho, Naoki, Katsuhiko, Ono, Fumie, Araki, Mitsugu, Kanada, Ryo, Ma, Biao, Hayashi, Yuichiro, Mimaki, Sachiyo, Yoh, Kiyotaka, Kobayashi, Susumu S., Kohno, Takashi, Okuno, Yasushi, Goto, Koichi, Tsuchihara, Katsuya, Soejima, Kenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525482/
https://www.ncbi.nlm.nih.gov/pubmed/31043566
http://dx.doi.org/10.1073/pnas.1819430116

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