Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement

G protein-coupled receptors (GPCRs) are key biological switches that transmit both internal and external stimuli into the cell interior. Among the GPCRs, the “light receptor” rhodopsin has been shown to activate with a rearrangement of the transmembrane (TM) helix bundle within ∼1 ms, while all othe...

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Detalles Bibliográficos
Autores principales: Grushevskyi, Eugene O., Kukaj, Taulant, Schmauder, Ralf, Bock, Andreas, Zabel, Ulrike, Schwabe, Tina, Benndorf, Klaus, Lohse, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525499/
https://www.ncbi.nlm.nih.gov/pubmed/31023886
http://dx.doi.org/10.1073/pnas.1900261116

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