Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes

Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription. PARP-1 consists of three functional domains: the N-terminal DNA-binding domain (DBD) containing three zinc fingers, the automodification dom...

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Detalles Bibliográficos
Autores principales: Thomas, Colin, Ji, Yingbiao, Wu, Chao, Datz, Haily, Boyle, Cody, MacLeod, Brett, Patel, Shri, Ampofo, Michelle, Currie, Michelle, Harbin, Jonathan, Pechenkina, Kate, Lodhi, Niraj, Johnson, Sarah J., Tulin, Alexei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525528/
https://www.ncbi.nlm.nih.gov/pubmed/31028139
http://dx.doi.org/10.1073/pnas.1901183116

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