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Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome
OBJECTIVES: To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness. METHODS: From our cohort (n = 608), we identifi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525628/ https://www.ncbi.nlm.nih.gov/pubmed/31168409 http://dx.doi.org/10.1136/rmdopen-2018-000885 |
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author | Hackett, Kate L Davies, Kristen Tarn, Jessica Bragg, Rebecca Hargreaves, Ben Miyamoto, Samira McMeekin, Peter Mitchell, Sheryl Bowman, Simon Price, Elizabeth J Pease, Colin Emery, Paul Andrews, Jacqueline Lanyon, Peter Hunter, John Gupta, Monica Bombardieri, Michele Sutcliffe, Nurhan Pitzalis, Costantino McLaren, John Cooper, Annie Regan, Marian Giles, Ian Isenberg, David Vadivelu, Saravan Coady, David Dasgupta, Bhaskar McHugh, Neil Young-Min, Steven Moots, Robert Gendi, Nagui Akil, Mohammed Griffiths, Bridget Lendrem, Dennis W Ng, Wan-Fai |
author_facet | Hackett, Kate L Davies, Kristen Tarn, Jessica Bragg, Rebecca Hargreaves, Ben Miyamoto, Samira McMeekin, Peter Mitchell, Sheryl Bowman, Simon Price, Elizabeth J Pease, Colin Emery, Paul Andrews, Jacqueline Lanyon, Peter Hunter, John Gupta, Monica Bombardieri, Michele Sutcliffe, Nurhan Pitzalis, Costantino McLaren, John Cooper, Annie Regan, Marian Giles, Ian Isenberg, David Vadivelu, Saravan Coady, David Dasgupta, Bhaskar McHugh, Neil Young-Min, Steven Moots, Robert Gendi, Nagui Akil, Mohammed Griffiths, Bridget Lendrem, Dennis W Ng, Wan-Fai |
author_sort | Hackett, Kate L |
collection | PubMed |
description | OBJECTIVES: To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness. METHODS: From our cohort (n = 608), we identified those with comorbidities associated with fatigue, and those taking medications associated with drowsiness. We constructed dummy variables, permitting the contribution of these potentially assignable causes of fatigue to be assessed. Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables. RESULTS: Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). In addition, dryness was strongly associated with physical fatigue (p ≤ 0.0001). These effects were observed even after adjustment for comorbidities associated with fatigue or medications associated with drowsiness. CONCLUSIONS: These findings support further research and clinical interventions targeting pain, dryness, depression and sleep to improve fatigue in patients with pSS. This finding is robust to both the effect of other comorbidities associated with fatigue and medications associated with drowsiness. |
format | Online Article Text |
id | pubmed-6525628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-65256282019-06-05 Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome Hackett, Kate L Davies, Kristen Tarn, Jessica Bragg, Rebecca Hargreaves, Ben Miyamoto, Samira McMeekin, Peter Mitchell, Sheryl Bowman, Simon Price, Elizabeth J Pease, Colin Emery, Paul Andrews, Jacqueline Lanyon, Peter Hunter, John Gupta, Monica Bombardieri, Michele Sutcliffe, Nurhan Pitzalis, Costantino McLaren, John Cooper, Annie Regan, Marian Giles, Ian Isenberg, David Vadivelu, Saravan Coady, David Dasgupta, Bhaskar McHugh, Neil Young-Min, Steven Moots, Robert Gendi, Nagui Akil, Mohammed Griffiths, Bridget Lendrem, Dennis W Ng, Wan-Fai RMD Open Sjögren Syndrome OBJECTIVES: To report on fatigue in patients from the United Kingdom primary Sjögren’s syndrome (pSS) registry identifying factors associated with fatigue and robust to assignable causes such as comorbidities and medications associated with drowsiness. METHODS: From our cohort (n = 608), we identified those with comorbidities associated with fatigue, and those taking medications associated with drowsiness. We constructed dummy variables, permitting the contribution of these potentially assignable causes of fatigue to be assessed. Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables. RESULTS: Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). In addition, dryness was strongly associated with physical fatigue (p ≤ 0.0001). These effects were observed even after adjustment for comorbidities associated with fatigue or medications associated with drowsiness. CONCLUSIONS: These findings support further research and clinical interventions targeting pain, dryness, depression and sleep to improve fatigue in patients with pSS. This finding is robust to both the effect of other comorbidities associated with fatigue and medications associated with drowsiness. BMJ Publishing Group 2019-04-24 /pmc/articles/PMC6525628/ /pubmed/31168409 http://dx.doi.org/10.1136/rmdopen-2018-000885 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Sjögren Syndrome Hackett, Kate L Davies, Kristen Tarn, Jessica Bragg, Rebecca Hargreaves, Ben Miyamoto, Samira McMeekin, Peter Mitchell, Sheryl Bowman, Simon Price, Elizabeth J Pease, Colin Emery, Paul Andrews, Jacqueline Lanyon, Peter Hunter, John Gupta, Monica Bombardieri, Michele Sutcliffe, Nurhan Pitzalis, Costantino McLaren, John Cooper, Annie Regan, Marian Giles, Ian Isenberg, David Vadivelu, Saravan Coady, David Dasgupta, Bhaskar McHugh, Neil Young-Min, Steven Moots, Robert Gendi, Nagui Akil, Mohammed Griffiths, Bridget Lendrem, Dennis W Ng, Wan-Fai Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title | Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title_full | Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title_fullStr | Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title_full_unstemmed | Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title_short | Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome |
title_sort | pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary sjögren’s syndrome |
topic | Sjögren Syndrome |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525628/ https://www.ncbi.nlm.nih.gov/pubmed/31168409 http://dx.doi.org/10.1136/rmdopen-2018-000885 |
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