Improving the sensitivity of FT-NMR spectroscopy by apodization weighted sampling

Apodization weighted acquisition is a simple approach to enhance the sensitivity of multidimensional NMR spectra by scaling the number of scans during acquisition of the indirect dimension(s). The signal content of the resulting spectra is identical to conventionally sampled data, yet the spectra show improved signal-to-noise ratios. There are no special requirements for data acquisition and processing: the time-domain data can be transformed with the same schemes used for conventionally recorded spectra, including Fourier transformation. The method is of general use in multidimensional liquid and solid state NMR experiments if the number of recorded transients per sampling point is bigger than the minimum required phase cycle of the pulse sequence. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10858-019-00243-7) contains supplementary material, which is available to authorized users.