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Role of Circular RNAs in Preeclampsia

Circular RNAs (circRNAs) are noncoding RNAs characterized by circular covalently closed structures, which are generated by back-splicing. circRNA is more stable and conserved than linear RNA and exists in various organisms. Preeclampsia (PE), a common hypertensive disorder of pregnancy, has a profou...

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Detalles Bibliográficos
Autores principales: Jia, Ningyi, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525895/
https://www.ncbi.nlm.nih.gov/pubmed/31191755
http://dx.doi.org/10.1155/2019/7237495
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author Jia, Ningyi
Li, Jian
author_facet Jia, Ningyi
Li, Jian
author_sort Jia, Ningyi
collection PubMed
description Circular RNAs (circRNAs) are noncoding RNAs characterized by circular covalently closed structures, which are generated by back-splicing. circRNA is more stable and conserved than linear RNA and exists in various organisms. Preeclampsia (PE), a common hypertensive disorder of pregnancy, has a profound impact on maternal and neonatal mortality and morbidity. Recent studies demonstrated that circRNAs were differentially expressed in PE maternal-fetal interface compared with those in the control and might mediate pathological processes in pregnancy complications. However, the mechanisms of action of circRNAs in PE are still unclear. Here, we provide a comprehensive review on the current state of knowledge on circRNAs associated with PE. We summarize the known expression profiles of circRNAs and discuss their potential application as biomarkers of PE. The possible mechanisms underlying circRNA dysregulation in the etiology of PE are also explored.
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spelling pubmed-65258952019-06-12 Role of Circular RNAs in Preeclampsia Jia, Ningyi Li, Jian Dis Markers Review Article Circular RNAs (circRNAs) are noncoding RNAs characterized by circular covalently closed structures, which are generated by back-splicing. circRNA is more stable and conserved than linear RNA and exists in various organisms. Preeclampsia (PE), a common hypertensive disorder of pregnancy, has a profound impact on maternal and neonatal mortality and morbidity. Recent studies demonstrated that circRNAs were differentially expressed in PE maternal-fetal interface compared with those in the control and might mediate pathological processes in pregnancy complications. However, the mechanisms of action of circRNAs in PE are still unclear. Here, we provide a comprehensive review on the current state of knowledge on circRNAs associated with PE. We summarize the known expression profiles of circRNAs and discuss their potential application as biomarkers of PE. The possible mechanisms underlying circRNA dysregulation in the etiology of PE are also explored. Hindawi 2019-05-02 /pmc/articles/PMC6525895/ /pubmed/31191755 http://dx.doi.org/10.1155/2019/7237495 Text en Copyright © 2019 Ningyi Jia and Jian Li. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jia, Ningyi
Li, Jian
Role of Circular RNAs in Preeclampsia
title Role of Circular RNAs in Preeclampsia
title_full Role of Circular RNAs in Preeclampsia
title_fullStr Role of Circular RNAs in Preeclampsia
title_full_unstemmed Role of Circular RNAs in Preeclampsia
title_short Role of Circular RNAs in Preeclampsia
title_sort role of circular rnas in preeclampsia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525895/
https://www.ncbi.nlm.nih.gov/pubmed/31191755
http://dx.doi.org/10.1155/2019/7237495
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