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Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor

OBJECTIVES: Differentiating gastrointestinal stromal tumor (GIST) from other submucosal tumors (SMTs) is important in diagnosing SMT. GIST is an immunohistological diagnosis that cannot be made from images alone. Tissue sampling of tumor sites is thus becoming increasingly important. In this study,...

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Autores principales: Mizukami, Kazuhiro, Matsunari, Osamu, Ogawa, Ryo, Hirashita, Yuka, Okamoto, Kazuhisa, Fukuda, Kensuke, Sonoda, Akira, Akiyama, Hidetoshi, Ozaka, Sotaro, Kawahara, Yoshinari, Okimoto, Tadayoshi, Kodama, Masaaki, Murakami, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525918/
https://www.ncbi.nlm.nih.gov/pubmed/31191643
http://dx.doi.org/10.1155/2019/3121695
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author Mizukami, Kazuhiro
Matsunari, Osamu
Ogawa, Ryo
Hirashita, Yuka
Okamoto, Kazuhisa
Fukuda, Kensuke
Sonoda, Akira
Akiyama, Hidetoshi
Ozaka, Sotaro
Kawahara, Yoshinari
Okimoto, Tadayoshi
Kodama, Masaaki
Murakami, Kazunari
author_facet Mizukami, Kazuhiro
Matsunari, Osamu
Ogawa, Ryo
Hirashita, Yuka
Okamoto, Kazuhisa
Fukuda, Kensuke
Sonoda, Akira
Akiyama, Hidetoshi
Ozaka, Sotaro
Kawahara, Yoshinari
Okimoto, Tadayoshi
Kodama, Masaaki
Murakami, Kazunari
author_sort Mizukami, Kazuhiro
collection PubMed
description OBJECTIVES: Differentiating gastrointestinal stromal tumor (GIST) from other submucosal tumors (SMTs) is important in diagnosing SMT. GIST is an immunohistological diagnosis that cannot be made from images alone. Tissue sampling of tumor sites is thus becoming increasingly important. In this study, the utility and associated complications of mucosal cutting biopsy (MCB) for gastric SMTs were investigated. METHODS: This was a case series study. The subjects were patients aged ≥20 years old in whom an SMT was seen on esophagogastroduodenography and who underwent MCB between January 2012 and December 2016. Patient information, endoscopy findings, gastric SMT size, pathological diagnosis, and other information were gathered from medical records. The SMT size was the maximum diameter that could be visualized on EUS. The pathological diagnosis was made with hematoxylin-eosin staining, with immunostaining added to diagnose GIST. The endpoint was the histopathological diagnostic yield. Risk assessment using the Miettinen classification and modified Fletcher classification was also done for GISTs treated with surgery. RESULTS: The mean tumor diameter was 15.4 mm. The tumor diameter was ≥20 mm in seven patients and <20 mm in 23 patients. The tissue-acquiring rate was 93.3%. A histological diagnosis could not be made in two patients. The only complication was that bleeding required endoscopic hemostasis during the procedure in one patient, but no subsequent bleeding or no postoperative bleeding was seen. CONCLUSIONS: MCB is an appropriate and safe procedure in the diagnosis of gastric SMTs. Many hospitals will be able to perform MCB if they have the environment, including skills and equipment, to perform endoscopic submucosal dissection.
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spelling pubmed-65259182019-06-12 Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor Mizukami, Kazuhiro Matsunari, Osamu Ogawa, Ryo Hirashita, Yuka Okamoto, Kazuhisa Fukuda, Kensuke Sonoda, Akira Akiyama, Hidetoshi Ozaka, Sotaro Kawahara, Yoshinari Okimoto, Tadayoshi Kodama, Masaaki Murakami, Kazunari Gastroenterol Res Pract Research Article OBJECTIVES: Differentiating gastrointestinal stromal tumor (GIST) from other submucosal tumors (SMTs) is important in diagnosing SMT. GIST is an immunohistological diagnosis that cannot be made from images alone. Tissue sampling of tumor sites is thus becoming increasingly important. In this study, the utility and associated complications of mucosal cutting biopsy (MCB) for gastric SMTs were investigated. METHODS: This was a case series study. The subjects were patients aged ≥20 years old in whom an SMT was seen on esophagogastroduodenography and who underwent MCB between January 2012 and December 2016. Patient information, endoscopy findings, gastric SMT size, pathological diagnosis, and other information were gathered from medical records. The SMT size was the maximum diameter that could be visualized on EUS. The pathological diagnosis was made with hematoxylin-eosin staining, with immunostaining added to diagnose GIST. The endpoint was the histopathological diagnostic yield. Risk assessment using the Miettinen classification and modified Fletcher classification was also done for GISTs treated with surgery. RESULTS: The mean tumor diameter was 15.4 mm. The tumor diameter was ≥20 mm in seven patients and <20 mm in 23 patients. The tissue-acquiring rate was 93.3%. A histological diagnosis could not be made in two patients. The only complication was that bleeding required endoscopic hemostasis during the procedure in one patient, but no subsequent bleeding or no postoperative bleeding was seen. CONCLUSIONS: MCB is an appropriate and safe procedure in the diagnosis of gastric SMTs. Many hospitals will be able to perform MCB if they have the environment, including skills and equipment, to perform endoscopic submucosal dissection. Hindawi 2019-05-02 /pmc/articles/PMC6525918/ /pubmed/31191643 http://dx.doi.org/10.1155/2019/3121695 Text en Copyright © 2019 Kazuhiro Mizukami et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mizukami, Kazuhiro
Matsunari, Osamu
Ogawa, Ryo
Hirashita, Yuka
Okamoto, Kazuhisa
Fukuda, Kensuke
Sonoda, Akira
Akiyama, Hidetoshi
Ozaka, Sotaro
Kawahara, Yoshinari
Okimoto, Tadayoshi
Kodama, Masaaki
Murakami, Kazunari
Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title_full Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title_fullStr Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title_full_unstemmed Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title_short Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor
title_sort examine the availability and safety of mucosal cutting biopsy technique for diagnosis of gastric submucosal tumor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525918/
https://www.ncbi.nlm.nih.gov/pubmed/31191643
http://dx.doi.org/10.1155/2019/3121695
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