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Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals

Osteoarthritis (OA) is a degenerative disease, promoted by abnormal chronic mechanical loading over the joint, for instance, due to excessive body mass. Patients frequently report pain, fatigue, and limitations in specific functional daily activities. Regarding the treatment of OA, two nonpharmacolo...

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Detalles Bibliográficos
Autores principales: Morouço, Pedro, Fernandes, Cristiana, Santos-Rocha, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525949/
https://www.ncbi.nlm.nih.gov/pubmed/31192012
http://dx.doi.org/10.1155/2019/1935806
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author Morouço, Pedro
Fernandes, Cristiana
Santos-Rocha, Rita
author_facet Morouço, Pedro
Fernandes, Cristiana
Santos-Rocha, Rita
author_sort Morouço, Pedro
collection PubMed
description Osteoarthritis (OA) is a degenerative disease, promoted by abnormal chronic mechanical loading over the joint, for instance, due to excessive body mass. Patients frequently report pain, fatigue, and limitations in specific functional daily activities. Regarding the treatment of OA, two nonpharmacological options are available. However, it is not clear which type and intensity of exercise have better outcomes in treatment and how tissue engineering can be a promising field due to the mechanical load implants will suffer. The aims of this work were to investigate (1) the main characteristics, prevalence, and consequences of OA; (2) the exercise prescription guidelines and whether exercise interventions have a positive effect on OA treatment; and (3) the novel improvements on tissue engineering for OA treatment. Both patients and practitioners should be aware that benefits may come from prescribed and supervised exercise. Recent studies have highlighted that an optimal balance between exercise and nutritional income should be widely recommended. Regarding tissue engineering, significant steps towards the development of implants that mimic the native tissue have been taken. Thus, further studies should focus on the impact that exercise (repetitive loading) might have on cartilage regeneration. Finally, suggestions for future research were proposed.
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spelling pubmed-65259492019-06-12 Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals Morouço, Pedro Fernandes, Cristiana Santos-Rocha, Rita J Aging Res Review Article Osteoarthritis (OA) is a degenerative disease, promoted by abnormal chronic mechanical loading over the joint, for instance, due to excessive body mass. Patients frequently report pain, fatigue, and limitations in specific functional daily activities. Regarding the treatment of OA, two nonpharmacological options are available. However, it is not clear which type and intensity of exercise have better outcomes in treatment and how tissue engineering can be a promising field due to the mechanical load implants will suffer. The aims of this work were to investigate (1) the main characteristics, prevalence, and consequences of OA; (2) the exercise prescription guidelines and whether exercise interventions have a positive effect on OA treatment; and (3) the novel improvements on tissue engineering for OA treatment. Both patients and practitioners should be aware that benefits may come from prescribed and supervised exercise. Recent studies have highlighted that an optimal balance between exercise and nutritional income should be widely recommended. Regarding tissue engineering, significant steps towards the development of implants that mimic the native tissue have been taken. Thus, further studies should focus on the impact that exercise (repetitive loading) might have on cartilage regeneration. Finally, suggestions for future research were proposed. Hindawi 2019-05-02 /pmc/articles/PMC6525949/ /pubmed/31192012 http://dx.doi.org/10.1155/2019/1935806 Text en Copyright © 2019 Pedro Morouço et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Morouço, Pedro
Fernandes, Cristiana
Santos-Rocha, Rita
Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title_full Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title_fullStr Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title_full_unstemmed Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title_short Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals
title_sort osteoarthritis, exercise, and tissue engineering: a stimulating triad for health professionals
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525949/
https://www.ncbi.nlm.nih.gov/pubmed/31192012
http://dx.doi.org/10.1155/2019/1935806
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