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Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia

BACKGROUND: Streptococcus pneumoniae is the cause of a highly lethal form of meningitis in humans. Microglial cells in the brain represent the first line of defense against pathogens, and they participate in the inflammatory response. The cholesterol-dependent cytolysin pneumolysin and the bacterial...

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Detalles Bibliográficos
Autores principales:	Hupp, Sabrina, Grandgirard, Denis, Mitchell, Timothy J., Leib, Stephen L., Hathaway, Lucy J., Iliev, Asparouh I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525981/ https://www.ncbi.nlm.nih.gov/pubmed/31103037 http://dx.doi.org/10.1186/s12974-019-1491-7

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