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Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia
BACKGROUND: Streptococcus pneumoniae is the cause of a highly lethal form of meningitis in humans. Microglial cells in the brain represent the first line of defense against pathogens, and they participate in the inflammatory response. The cholesterol-dependent cytolysin pneumolysin and the bacterial...
Autores principales: | Hupp, Sabrina, Grandgirard, Denis, Mitchell, Timothy J., Leib, Stephen L., Hathaway, Lucy J., Iliev, Asparouh I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525981/ https://www.ncbi.nlm.nih.gov/pubmed/31103037 http://dx.doi.org/10.1186/s12974-019-1491-7 |
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