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Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α

Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression and chemoresistance of liver cancer. However, no agent targeting LCSC is available in the clinic to date. Here, we investigated the effects of targeting protein arginine methyltransferase 5 (PRMT5), an epigen...

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Detalles Bibliográficos
Autores principales:	Zheng, Bai-Nan, Ding, Chen-Hong, Chen, Shi-Jie, Zhu, Kongkai, Shao, Jingwei, Feng, Jifeng, Xu, Wen-Ping, Cai, Ling-Yan, Zhu, Chang-Peng, Duan, Wenhu, Ding, Jin, Zhang, Xin, Luo, Cheng, Xie, Wei-Fen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525986/ https://www.ncbi.nlm.nih.gov/pubmed/31131056 http://dx.doi.org/10.7150/thno.32344

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