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Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice

Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability of rodents in simple and direct ways, which includes reciprocal social interaction, juv...

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Autores principales: Kim, Do Gyeong, Gonzales, Edson Luck, Kim, Seonmin, Kim, Yujeong, Adil, Keremkleroo Jym, Jeon, Se Jin, Cho, Kyu Suk, Kwon, Kyoung Ja, Shin, Chan Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526108/
https://www.ncbi.nlm.nih.gov/pubmed/31138992
http://dx.doi.org/10.5607/en.2019.28.2.247
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author Kim, Do Gyeong
Gonzales, Edson Luck
Kim, Seonmin
Kim, Yujeong
Adil, Keremkleroo Jym
Jeon, Se Jin
Cho, Kyu Suk
Kwon, Kyoung Ja
Shin, Chan Young
author_facet Kim, Do Gyeong
Gonzales, Edson Luck
Kim, Seonmin
Kim, Yujeong
Adil, Keremkleroo Jym
Jeon, Se Jin
Cho, Kyu Suk
Kwon, Kyoung Ja
Shin, Chan Young
author_sort Kim, Do Gyeong
collection PubMed
description Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability of rodents in simple and direct ways, which includes reciprocal social interaction, juvenile social play, and three-chamber social tests. There are possible confounding factors while performing some of these tasks, such as aggression, avoidance of interaction by the stimulus mouse, exposure to a new environment, and lengthy procedures. The present study devised a method to complement these shortcomings and measure sociability as a group in the home cage setting, which prevents group-housed mice from isolation or exposure to a new environment. The home cage social test can allow high-throughput screening of social behaviors in a short amount of time. We developed two types of home cage setup: a home cage social target interaction test that measures sociability by putting the wire cage in the center area of the cage and a home cage two-choice sociability and social preference test that measures both sociability or social preference by putting cage racks at opposite sides of the cage. Interestingly, our results showed that the two types of home cage setup that we used in this study can extract abnormal social behaviors in various animal models, similar to the three-chamber assay. Thus, this study establishes a new and effective method to measure sociability or social preference that could be a complementary assay to evaluate the social behavior of mice in various setup conditions.
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spelling pubmed-65261082019-05-28 Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice Kim, Do Gyeong Gonzales, Edson Luck Kim, Seonmin Kim, Yujeong Adil, Keremkleroo Jym Jeon, Se Jin Cho, Kyu Suk Kwon, Kyoung Ja Shin, Chan Young Exp Neurobiol Original Article Sociability is the disposition to interact with one another. Rodents have a rich repertoire of social behaviors and demonstrate strong sociability. Various methods have been established to measure the sociability of rodents in simple and direct ways, which includes reciprocal social interaction, juvenile social play, and three-chamber social tests. There are possible confounding factors while performing some of these tasks, such as aggression, avoidance of interaction by the stimulus mouse, exposure to a new environment, and lengthy procedures. The present study devised a method to complement these shortcomings and measure sociability as a group in the home cage setting, which prevents group-housed mice from isolation or exposure to a new environment. The home cage social test can allow high-throughput screening of social behaviors in a short amount of time. We developed two types of home cage setup: a home cage social target interaction test that measures sociability by putting the wire cage in the center area of the cage and a home cage two-choice sociability and social preference test that measures both sociability or social preference by putting cage racks at opposite sides of the cage. Interestingly, our results showed that the two types of home cage setup that we used in this study can extract abnormal social behaviors in various animal models, similar to the three-chamber assay. Thus, this study establishes a new and effective method to measure sociability or social preference that could be a complementary assay to evaluate the social behavior of mice in various setup conditions. The Korean Society for Brain and Neural Science 2019-04 2019-04-30 /pmc/articles/PMC6526108/ /pubmed/31138992 http://dx.doi.org/10.5607/en.2019.28.2.247 Text en Copyright © Experimental Neurobiology 2019. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Do Gyeong
Gonzales, Edson Luck
Kim, Seonmin
Kim, Yujeong
Adil, Keremkleroo Jym
Jeon, Se Jin
Cho, Kyu Suk
Kwon, Kyoung Ja
Shin, Chan Young
Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title_full Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title_fullStr Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title_full_unstemmed Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title_short Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
title_sort social interaction test in home cage as a novel and ethological measure of social behavior in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526108/
https://www.ncbi.nlm.nih.gov/pubmed/31138992
http://dx.doi.org/10.5607/en.2019.28.2.247
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