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Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). Here we show that isotype and intrinsic...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526162/ https://www.ncbi.nlm.nih.gov/pubmed/31105267 http://dx.doi.org/10.1038/s41467-019-10088-1 |