SPI1/PU.1 controls fibroblast polarization and tissue fibrosis

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix which lead to scaring and organ failure. In contrast, the hallmark feature of fibroblasts in...

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Detalles Bibliográficos
Autores principales: Wohlfahrt, Thomas, Rauber, Simon, Uebe, Steffen, Luber, Markus, Soare, Alina, Ekici, Arif, Weber, Stefanie, Matei, Alexandru-Emil, Chen, Chih-Wei, Maier, Christiane, Karouzakis, Emmanuel, Kiener, Hans P., Pachera, Elena, Dees, Clara, Beyer, Christian, Daniel, Christoph, Gelse, Kolja, Kremer, Andreas E., Naschberger, Elisabeth, Stürzl, Michael, Butter, Falk, Sticherling, Michael, Finotto, Susetta, Kreuter, Alexander, Kaplan, Mark H., Jüngel, Astrid, Gay, Steffen, Nutt, Stephen L., Boykin, David W., Poon, Gregory M. K., Distler, Oliver, Schett, Georg, Distler, Jörg H. W., Ramming, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526281/
https://www.ncbi.nlm.nih.gov/pubmed/30700907
http://dx.doi.org/10.1038/s41586-019-0896-x

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