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A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP

To evade the immune system, the lethal human pathogen Streptococcus pyogenes produces SpyCEP, an enzyme that cleaves the C-terminal α-helix of CXCL8, resulting in markedly impaired recruitment of neutrophils to sites of invasive infection. The basis for chemokine inactivation by SpyCEP is, however,...

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Detalles Bibliográficos
Autores principales:	Goldblatt, Jennifer, Lawrenson, Richard Ashley, Muir, Luke, Dattani, Saloni, Hoffland, Ashley, Tsuchiya, Tomoko, Kanegasaki, Shiro, Sriskandan, Shiranee, Pease, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2019
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526389/ https://www.ncbi.nlm.nih.gov/pubmed/31010851 http://dx.doi.org/10.4049/jimmunol.1801688

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