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Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding

Sonic hedgehog (Shh) signaling plays a tumor-promoting role in many epithelial cancers. Cancer cells produce soluble a Shh that signals to distant stromal cells that express the receptor Patched (Ptc). These receiving cells respond by producing other soluble factors that promote cancer cell growth,...

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Detalles Bibliográficos
Autores principales:	Manikowski, Dominique, Jakobs, Petra, Jboor, Hamodah, Grobe, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526471/ https://www.ncbi.nlm.nih.gov/pubmed/31018591 http://dx.doi.org/10.3390/molecules24081607

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