A Fragment of Apolipoprotein E4 Leads to the Downregulation of a CXorf56 Homologue, a Novel ER-Associated Protein, and Activation of BV2 Microglial Cells

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer's disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fra...

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Detalles Bibliográficos
Autores principales: Pollock, Tanner B., Mack, Jacob M., Day, Ryan J., Isho, Noail F., Brown, Raquel J., Oxford, Alexandra E., Morrison, Brad E., Hayden, Eric J., Rohn, Troy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526552/
https://www.ncbi.nlm.nih.gov/pubmed/31198491
http://dx.doi.org/10.1155/2019/5123565

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