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Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. Howe...

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Autores principales: Xu, Xiaofeng, Hu, Haochang, Lin, Ying, Huang, Fangzhong, Ji, Huihui, Li, Yin, Lin, Shaoyi, Chen, Xiaomin, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526555/
https://www.ncbi.nlm.nih.gov/pubmed/31198785
http://dx.doi.org/10.1155/2019/5046867
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author Xu, Xiaofeng
Hu, Haochang
Lin, Ying
Huang, Fangzhong
Ji, Huihui
Li, Yin
Lin, Shaoyi
Chen, Xiaomin
Duan, Shiwei
author_facet Xu, Xiaofeng
Hu, Haochang
Lin, Ying
Huang, Fangzhong
Ji, Huihui
Li, Yin
Lin, Shaoyi
Chen, Xiaomin
Duan, Shiwei
author_sort Xu, Xiaofeng
collection PubMed
description Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study.
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spelling pubmed-65265552019-06-13 Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis Xu, Xiaofeng Hu, Haochang Lin, Ying Huang, Fangzhong Ji, Huihui Li, Yin Lin, Shaoyi Chen, Xiaomin Duan, Shiwei Biomed Res Int Review Article Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study. Hindawi 2019-05-06 /pmc/articles/PMC6526555/ /pubmed/31198785 http://dx.doi.org/10.1155/2019/5046867 Text en Copyright © 2019 Xiaofeng Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xu, Xiaofeng
Hu, Haochang
Lin, Ying
Huang, Fangzhong
Ji, Huihui
Li, Yin
Lin, Shaoyi
Chen, Xiaomin
Duan, Shiwei
Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title_full Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title_fullStr Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title_full_unstemmed Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title_short Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
title_sort differences in leukocyte telomere length between coronary heart disease and normal population: a multipopulation meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526555/
https://www.ncbi.nlm.nih.gov/pubmed/31198785
http://dx.doi.org/10.1155/2019/5046867
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