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Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis
Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. Howe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526555/ https://www.ncbi.nlm.nih.gov/pubmed/31198785 http://dx.doi.org/10.1155/2019/5046867 |
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author | Xu, Xiaofeng Hu, Haochang Lin, Ying Huang, Fangzhong Ji, Huihui Li, Yin Lin, Shaoyi Chen, Xiaomin Duan, Shiwei |
author_facet | Xu, Xiaofeng Hu, Haochang Lin, Ying Huang, Fangzhong Ji, Huihui Li, Yin Lin, Shaoyi Chen, Xiaomin Duan, Shiwei |
author_sort | Xu, Xiaofeng |
collection | PubMed |
description | Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study. |
format | Online Article Text |
id | pubmed-6526555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65265552019-06-13 Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis Xu, Xiaofeng Hu, Haochang Lin, Ying Huang, Fangzhong Ji, Huihui Li, Yin Lin, Shaoyi Chen, Xiaomin Duan, Shiwei Biomed Res Int Review Article Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study. Hindawi 2019-05-06 /pmc/articles/PMC6526555/ /pubmed/31198785 http://dx.doi.org/10.1155/2019/5046867 Text en Copyright © 2019 Xiaofeng Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xu, Xiaofeng Hu, Haochang Lin, Ying Huang, Fangzhong Ji, Huihui Li, Yin Lin, Shaoyi Chen, Xiaomin Duan, Shiwei Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title | Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title_full | Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title_fullStr | Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title_full_unstemmed | Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title_short | Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis |
title_sort | differences in leukocyte telomere length between coronary heart disease and normal population: a multipopulation meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526555/ https://www.ncbi.nlm.nih.gov/pubmed/31198785 http://dx.doi.org/10.1155/2019/5046867 |
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