Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at the expense of α-ketoglutarate (α-KG) and NADPH. To overcome metabolic stress...

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Detalles Bibliográficos
Autores principales: Peeters, Tom H., Lenting, Krissie, Breukels, Vincent, van Lith, Sanne A. M., van den Heuvel, Corina N. A. M., Molenaar, Remco, van Rooij, Arno, Wevers, Ron, Span, Paul N., Heerschap, Arend, Leenders, William P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526618/
https://www.ncbi.nlm.nih.gov/pubmed/31139406
http://dx.doi.org/10.1186/s40170-019-0198-7

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