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Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study

A number of studies have shown the bifidogenic effects of either probiotic bifidobacteria or inulin, and this bifidogenic shift in the composition of the colonic microbiota is likely the basis for their positive impact on human health. This study aimed to evaluate the effects of synbiotics containin...

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Autores principales: Anzawa, Daisuke, Mawatari, Takashi, Tanaka, Yoshiyuki, Yamamoto, Mio, Genda, Tomomi, Takahashi, Shota, Nishijima, Tomohiko, Kamasaka, Hiroshi, Suzuki, Satoru, Kuriki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526661/
https://www.ncbi.nlm.nih.gov/pubmed/31139397
http://dx.doi.org/10.1002/fsn3.1033
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author Anzawa, Daisuke
Mawatari, Takashi
Tanaka, Yoshiyuki
Yamamoto, Mio
Genda, Tomomi
Takahashi, Shota
Nishijima, Tomohiko
Kamasaka, Hiroshi
Suzuki, Satoru
Kuriki, Takashi
author_facet Anzawa, Daisuke
Mawatari, Takashi
Tanaka, Yoshiyuki
Yamamoto, Mio
Genda, Tomomi
Takahashi, Shota
Nishijima, Tomohiko
Kamasaka, Hiroshi
Suzuki, Satoru
Kuriki, Takashi
author_sort Anzawa, Daisuke
collection PubMed
description A number of studies have shown the bifidogenic effects of either probiotic bifidobacteria or inulin, and this bifidogenic shift in the composition of the colonic microbiota is likely the basis for their positive impact on human health. This study aimed to evaluate the effects of synbiotics containing the probiotic bacterium Bifidobacterium animalis subsp. lactis (B. lactis) GCL2505 and inulin on the levels of intestinal bifidobacteria compared with B. lactis GCL2505 alone. A randomized, double‐blind, placebo‐controlled, crossover trial was carried out involving 60 healthy subjects with a tendency for constipation using fermented milk containing B. lactis GCL2505 and inulin (synbiotic), only B. lactis GCL2505 (probiotic), and placebo. Fecal samples were collected at the end of each 2‐week intervention period, and the bifidobacterial count was analyzed by quantitative real‐time PCR. The numbers of total bifidobacteria and B. lactis in feces were significantly increased during the probiotic and synbiotic intake periods compared with the placebo intake period. Furthermore, the numbers of total bifidobacteria and endogenous bifidobacteria were significantly higher in the synbiotic intake period compared with the probiotic intake period, while there was no difference in the number of B. lactis. These results suggested that the synbiotics containing B. lactis GCL2505 and inulin had a greater effect on the number of bifidobacteria than a drink containing probiotics alone and could be useful for the improvement of the intestinal environment.
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spelling pubmed-65266612019-05-28 Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study Anzawa, Daisuke Mawatari, Takashi Tanaka, Yoshiyuki Yamamoto, Mio Genda, Tomomi Takahashi, Shota Nishijima, Tomohiko Kamasaka, Hiroshi Suzuki, Satoru Kuriki, Takashi Food Sci Nutr Original Research A number of studies have shown the bifidogenic effects of either probiotic bifidobacteria or inulin, and this bifidogenic shift in the composition of the colonic microbiota is likely the basis for their positive impact on human health. This study aimed to evaluate the effects of synbiotics containing the probiotic bacterium Bifidobacterium animalis subsp. lactis (B. lactis) GCL2505 and inulin on the levels of intestinal bifidobacteria compared with B. lactis GCL2505 alone. A randomized, double‐blind, placebo‐controlled, crossover trial was carried out involving 60 healthy subjects with a tendency for constipation using fermented milk containing B. lactis GCL2505 and inulin (synbiotic), only B. lactis GCL2505 (probiotic), and placebo. Fecal samples were collected at the end of each 2‐week intervention period, and the bifidobacterial count was analyzed by quantitative real‐time PCR. The numbers of total bifidobacteria and B. lactis in feces were significantly increased during the probiotic and synbiotic intake periods compared with the placebo intake period. Furthermore, the numbers of total bifidobacteria and endogenous bifidobacteria were significantly higher in the synbiotic intake period compared with the probiotic intake period, while there was no difference in the number of B. lactis. These results suggested that the synbiotics containing B. lactis GCL2505 and inulin had a greater effect on the number of bifidobacteria than a drink containing probiotics alone and could be useful for the improvement of the intestinal environment. John Wiley and Sons Inc. 2019-04-21 /pmc/articles/PMC6526661/ /pubmed/31139397 http://dx.doi.org/10.1002/fsn3.1033 Text en © 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Anzawa, Daisuke
Mawatari, Takashi
Tanaka, Yoshiyuki
Yamamoto, Mio
Genda, Tomomi
Takahashi, Shota
Nishijima, Tomohiko
Kamasaka, Hiroshi
Suzuki, Satoru
Kuriki, Takashi
Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title_full Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title_fullStr Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title_full_unstemmed Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title_short Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study
title_sort effects of synbiotics containing bifidobacterium animalis subsp. lactis gcl2505 and inulin on intestinal bifidobacteria: a randomized, placebo‐controlled, crossover study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526661/
https://www.ncbi.nlm.nih.gov/pubmed/31139397
http://dx.doi.org/10.1002/fsn3.1033
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