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Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known about the physiological brain region- and cell type-specific HTT expression pattern in wild...

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Detalles Bibliográficos
Autores principales:	Hartlage-Rübsamen, Maike, Ratz, Veronika, Zeitschel, Ulrike, Finzel, Lukas, Machner, Lisa, Köppen, Janett, Schulze, Anja, Demuth, Hans-Ulrich, von Hörsten, Stephan, Höfling, Corinna, Roßner, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526682/ https://www.ncbi.nlm.nih.gov/pubmed/31109380 http://dx.doi.org/10.1186/s40478-019-0726-2

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