The emerging role of human TBK1 in virus-induced autophagy

Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we d...

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Autores principales: Liyana, Ahmad, Vanessa, Sancho-Shimizu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526806/
https://www.ncbi.nlm.nih.gov/pubmed/30794036
http://dx.doi.org/10.1080/15548627.2019.1580513
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author Liyana, Ahmad
Vanessa, Sancho-Shimizu
author_facet Liyana, Ahmad
Vanessa, Sancho-Shimizu
author_sort Liyana, Ahmad
collection PubMed
description Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system.
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spelling pubmed-65268062019-05-29 The emerging role of human TBK1 in virus-induced autophagy Liyana, Ahmad Vanessa, Sancho-Shimizu Autophagy Commentary Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system. Taylor & Francis 2019-02-22 /pmc/articles/PMC6526806/ /pubmed/30794036 http://dx.doi.org/10.1080/15548627.2019.1580513 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Liyana, Ahmad
Vanessa, Sancho-Shimizu
The emerging role of human TBK1 in virus-induced autophagy
title The emerging role of human TBK1 in virus-induced autophagy
title_full The emerging role of human TBK1 in virus-induced autophagy
title_fullStr The emerging role of human TBK1 in virus-induced autophagy
title_full_unstemmed The emerging role of human TBK1 in virus-induced autophagy
title_short The emerging role of human TBK1 in virus-induced autophagy
title_sort emerging role of human tbk1 in virus-induced autophagy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526806/
https://www.ncbi.nlm.nih.gov/pubmed/30794036
http://dx.doi.org/10.1080/15548627.2019.1580513
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