SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis

The intronic hexanucleotide expansion in the C9orf72 gene is one of the leading causes of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), two devastating neurodegenerative diseases. C9orf72 forms a heterodimer with SMCR8 (Smith-Magenis syndrome chromosome region, ca...

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Detalles Bibliográficos
Autores principales: Lan, Yungang, Sullivan, Peter M., Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526807/
https://www.ncbi.nlm.nih.gov/pubmed/30696333
http://dx.doi.org/10.1080/15548627.2019.1569914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526807/
https://www.ncbi.nlm.nih.gov/pubmed/30696333
http://dx.doi.org/10.1080/15548627.2019.1569914

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