Oxidation of Ethanol in the Brain and Its Consequences

Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetal...

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Autores principales: Deitrich, Richard, Zimatkin, Sergey, Pronko, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2006
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527035/
https://www.ncbi.nlm.nih.gov/pubmed/17718405
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author Deitrich, Richard
Zimatkin, Sergey
Pronko, Sergey
author_facet Deitrich, Richard
Zimatkin, Sergey
Pronko, Sergey
author_sort Deitrich, Richard
collection PubMed
description Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol.
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spelling pubmed-65270352019-05-28 Oxidation of Ethanol in the Brain and Its Consequences Deitrich, Richard Zimatkin, Sergey Pronko, Sergey Alcohol Res Health Articles Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol. National Institute on Alcohol Abuse and Alcoholism 2006 /pmc/articles/PMC6527035/ /pubmed/17718405 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Articles
Deitrich, Richard
Zimatkin, Sergey
Pronko, Sergey
Oxidation of Ethanol in the Brain and Its Consequences
title Oxidation of Ethanol in the Brain and Its Consequences
title_full Oxidation of Ethanol in the Brain and Its Consequences
title_fullStr Oxidation of Ethanol in the Brain and Its Consequences
title_full_unstemmed Oxidation of Ethanol in the Brain and Its Consequences
title_short Oxidation of Ethanol in the Brain and Its Consequences
title_sort oxidation of ethanol in the brain and its consequences
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527035/
https://www.ncbi.nlm.nih.gov/pubmed/17718405
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