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Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors

Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collect...

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Detalles Bibliográficos
Autores principales: Davis, Tiffany J., de Fiebre, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527039/
https://www.ncbi.nlm.nih.gov/pubmed/17373406
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author Davis, Tiffany J.
de Fiebre, Christopher M.
author_facet Davis, Tiffany J.
de Fiebre, Christopher M.
author_sort Davis, Tiffany J.
collection PubMed
description Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol’s and nicotine’s effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity.
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spelling pubmed-65270392019-05-28 Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors Davis, Tiffany J. de Fiebre, Christopher M. Alcohol Res Health Biological Mechanisms Although it has been known for many years that alcoholism and tobacco addiction often co-occur, relatively little information is available on the biological factors that regulate the co-use and abuse of nicotine and alcohol. In the brain, nicotine acts at several different types of receptors collectively known as nicotinic acetylcholine receptors (nAChRs). Alcohol also acts on at least some of these receptors, enhancing the function of some nAChR subtypes and inhibiting the activity of others. Chronic alcohol and nicotine administration also lead to changes in the numbers of nAChRs. Natural variations (i.e., polymorphisms) in the genes encoding different nAChR subunits may be associated with individual differences in the sensitivity to some of alcohol’s and nicotine’s effects. Finally, at least one subtype of nAChR may help protect cells against alcohol-induced neurotoxicity. National Institute on Alcohol Abuse and Alcoholism 2006 /pmc/articles/PMC6527039/ /pubmed/17373406 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Biological Mechanisms
Davis, Tiffany J.
de Fiebre, Christopher M.
Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title_full Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title_fullStr Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title_full_unstemmed Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title_short Alcohol’s Actions on Neuronal Nicotinic Acetylcholine Receptors
title_sort alcohol’s actions on neuronal nicotinic acetylcholine receptors
topic Biological Mechanisms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527039/
https://www.ncbi.nlm.nih.gov/pubmed/17373406
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