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Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors

Alcohol and nicotine are two of the oldest and most commonly used recreational drugs, and many people use both of them together. Although their ready availability likely contributes to the strong correlation between alcohol and nicotine use, several lines of evidence suggest that biological factors...

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Detalles Bibliográficos
Autores principales: Funk, Douglas, Marinelli, Peter W., Lê, Anh D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527043/
https://www.ncbi.nlm.nih.gov/pubmed/17373407
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author Funk, Douglas
Marinelli, Peter W.
Lê, Anh D.
author_facet Funk, Douglas
Marinelli, Peter W.
Lê, Anh D.
author_sort Funk, Douglas
collection PubMed
description Alcohol and nicotine are two of the oldest and most commonly used recreational drugs, and many people use both of them together. Although their ready availability likely contributes to the strong correlation between alcohol and nicotine use, several lines of evidence suggest that biological factors play a role as well. For example, both alcohol and nicotine act on a brain system called the mesolimbic dopamine system, which mediates the rewarding and reinforcing properties of both drugs. Modification of the activities of the mesolimbic dopamine system can interfere with the effects of both alcohol and nicotine. Another mechanism that may contribute to alcohol–nicotine interactions is cross-tolerance to the effects of both drugs. Finally, genetic studies in humans and of selectively bred mouse and rat strains suggest that shared genetic factors help determine a person’s liability to use or abuse both alcohol and nicotine.
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spelling pubmed-65270432019-05-28 Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors Funk, Douglas Marinelli, Peter W. Lê, Anh D. Alcohol Res Health Biological Mechanisms Alcohol and nicotine are two of the oldest and most commonly used recreational drugs, and many people use both of them together. Although their ready availability likely contributes to the strong correlation between alcohol and nicotine use, several lines of evidence suggest that biological factors play a role as well. For example, both alcohol and nicotine act on a brain system called the mesolimbic dopamine system, which mediates the rewarding and reinforcing properties of both drugs. Modification of the activities of the mesolimbic dopamine system can interfere with the effects of both alcohol and nicotine. Another mechanism that may contribute to alcohol–nicotine interactions is cross-tolerance to the effects of both drugs. Finally, genetic studies in humans and of selectively bred mouse and rat strains suggest that shared genetic factors help determine a person’s liability to use or abuse both alcohol and nicotine. National Institute on Alcohol Abuse and Alcoholism 2006 /pmc/articles/PMC6527043/ /pubmed/17373407 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Biological Mechanisms
Funk, Douglas
Marinelli, Peter W.
Lê, Anh D.
Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title_full Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title_fullStr Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title_full_unstemmed Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title_short Biological Processes Underlying Co-Use of Alcohol and Nicotine: Neuronal Mechanisms, Crosstolerance, and Genetic Factors
title_sort biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, crosstolerance, and genetic factors
topic Biological Mechanisms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527043/
https://www.ncbi.nlm.nih.gov/pubmed/17373407
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