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Generation of a novel HEK293 luciferase reporter cell line by CRISPR/Cas9-mediated site-specific integration in the genome to explore the transcriptional regulation of the PGRN gene

Progranulin has multiple functions in several physiological and pathological processes, including embryonic development, wound repair, tumorigenesis, inflammation and neurodegeneration. To investigate the transcriptional regulation of the PGRN gene, a luciferase knock-in reporter system was establis...

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Detalles Bibliográficos
Autores principales:	Li, Yanqing, Li, Sai, Li, Yan, Xia, Haibin, Mao, Qinwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527057/ https://www.ncbi.nlm.nih.gov/pubmed/31023186 http://dx.doi.org/10.1080/21655979.2019.1607126

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