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Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors

The lectin pathway (LP) of the complement system is an important antimicrobial defense mechanism, but it also contributes significantly to ischemia reperfusion injury (IRI) associated with myocardial infarct, stroke, and several other clinical conditions. Mannan-binding lectin–associated serine prot...

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Detalles Bibliográficos
Autores principales:	Szakács, Dávid, Kocsis, Andrea, Szász, Róbert, Gál, Péter, Pál, Gábor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527154/ https://www.ncbi.nlm.nih.gov/pubmed/30952698 http://dx.doi.org/10.1074/jbc.RA119.008315

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