Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings

Recent data support that the vaginal microbiota may alter mucosal pharmacokinetics (PK) of topically delivered microbicides. Our team developed an intravaginal ring (IVR) that delivers tenofovir (TFV) (8–10 mg/day) alone or with levonorgestrel (LNG) (20 ug/day). We evaluated the effect of IVRs on th...

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Detalles Bibliográficos
Autores principales: Thurman, Andrea Ries, Schwartz, Jill L., Ravel, Jacques, Gajer, Pawel, Marzinke, Mark A., Yousefieh, Nazita, Anderson, Sharon M., Doncel, Gustavo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527208/
https://www.ncbi.nlm.nih.gov/pubmed/31107913
http://dx.doi.org/10.1371/journal.pone.0217229

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